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It is often very easy to get fatigued. Depending on the cause, your fatigue can either be acute or chronic. Although the difference between acute and chronic fatigue lies mainly on the duration of symptoms, there’s no significant difference in how people respond to fatigue. 

Are you experiencing midday fatigue? Is afternoon slump your standard? You shouldn’t have it this way.

In this article, we will focus on brain fatigue and how to alleviate it using brain-boosting supplements. 

by Andy J. Skye    December 12, 2019


Brain fatigue, which is also called mental fatigue, is a health problem that occurs when you have excess and prolonged cognitive activity. Most people don’t comprehend fully what cognitive activity entails. Cognition is also known as higher functions and encompasses the following four factors:

  • Memory
  • Concentration
  • Intelligence and
  • Speech

The main reason why everyone is always fatigued is that we rely on our cognitive functions to navigate through the sheers of life. You may have overused your memory while doing an exam, or maintained your concentration in combat – or just involving yourself in intellectual discussions and perhaps, exercising your eloquence in front of an audience.

Whichever aspect of cognition you exercise, you are likely to send your brain into an overdrive which can contribute to your exhaustion, reduce your productivity and your overall cognitive performance.

What Causes Brain Fatigue?

Several factors can cause brain fatigue. Here are some of the most common:

  • Engaging in constant decision making

Decision making is an executive function of cognition. It is one of the most common causes of brain exhaustion. Decision making ranges from trivial activities like making decisions for your friends, to discussing serious issues in a board meeting.

  • Stress

Stress is a huge topic, not only because it is a common symptom for most people but it is also one of the major predisposing factors to anxiety and depression. Everything that causes stress triggers the release of the stress hormone, cortisol. When you are constantly stressed, the amount of cortisol you produce will overwhelm your body and your brain which may manifest as brain fatigue.

  • Being an over committer

It is not always healthy to assign yourself more work than you have time to complete. Overcommitting is not only unhealthy to the mind but also counterproductive. The excessive cognitive involvement in overcommitting can make you fatigued and predispose you to burnout.

  • Procrastination and avoidance

Procrastination is far more damaging to the brain than doing the actual task you’ve been avoiding. What happens in procrastination and avoidance is, your anxiety levels increase and depletes the essential neurotransmitters in your brain that keeps your mental health balanced.

  • Inadequate sleep

Getting adequate sleep is important for brain rejuvenation. The National Sleep Foundation recommends that adults should sleep for about 7 to 9 hours. Inadequate sleep makes your mind foggy and reduces your focus, productivity, alertness, and mood.

How to Tell That You Are Having Brain Fatigue

It is important to identify signs of fatigue to help you know if your symptoms are taking over your life. When fatigue sets in, you are most likely to present with symptoms such as lack of motivation, loss of appetite, persistent feeling of exhaustion and irritability. The following are some of the questions which can help you determine if you are suffering from brain fatigue:

  • Are you always struggling to stay awake at your desk when you work?
  • Have you become unable to make conclusive answers to simple decisions?
  • Do you always finish your day by simply collapsing on the couch?
  • Have you felt like the things which were once important to you are not important anymore?
  • Do you find it hard to concentrate on any work at hand because you are restless?
  • Do you struggle to get out of bed in the morning even when you are not sleepy?

If your answer is yes to any of these questions, then you are a candidate for treatment against fatigue. With the tremendous advancements in health and increased knowledge, people are nowadays orchestrating simple, natural, and safe ways to alleviate their symptoms to help boost their productivity.

It is this idea to boost mental health that saw the rise in popularity of nootropic supplements. 

Nowadays, mental breakdown is not a problem because nootropic supplements for fatigue have gone mainstream. Here are how nootropic supplements will help stop your brain fatigue.


Nootropics for brain fatigue are well known for their ability to reinvigorate a brain that was previously depleted of energy thereby improving cognitive functions, mood, and overall mental competence.

2016 study that was published in the journal of Evidence-Based Complementary and Alternative Medicine, found out that nootropics are potent cognitive enhances that helps in boosting your memory, improving your concentration, enhancing your ability to speak well and increasing your intelligence.

The research suggested that nootropics influence the effects of two main neurotransmitters in the brain – glutamate and acetylcholine. Glutamate is an essential neurotransmitter for cognitive functions.

The study found out that nootropic supplements increased the density of glutamate receptors, thus enhancing memory consolidation. It was also associated with improvement in short-term memory and other cognitive functions.

Cognitive dysfunction has also been associated with a reduction in the function of acetylcholine. It was found out that the administration of nootropic agents increased the levels of acetylcholine thus improving cognitive function.

Since brain fatigue occurs when your cognitive functions are deranged, these studies proved without a doubt that the administration of nootropic supplements is a cognitive booster for anyone with brain fatigue.

Consuming nootropics either as supplements or in food may be the only missing ingredient in your quest to battle fatigue and be effective at handling your responsibilities.


Stimulants are usually very quick in their actions to make you feel charged. However, their long-term use is not usually beneficial. See, stimulants work by increasing neurotransmitter activity the same way nootropics do. The difference is that stimulants don’t increase neurotransmitters – they only accelerate the activity of the available neurotransmitters.

This is dangerous because stimulants are notorious for depleting neurotransmitters in your brain thereby putting you in some sort of dependency mode. It is for this reason that most stimulants are associated with addiction.

Nootropic agents, on the other hand, do not only increase neurotransmitter activity. They also act as precursors for neurotransmitter synthesis, receptor boosters and enhancers of cellular energy production.

As a result, they do not deplete your neurotransmitters and are not associated with addiction. 

Prolonged use of nootropic agents may also not impair your cognitive functions, unlike stimulants which impair cognitive functions in the long term.

1. Stimulants


  • Rapid onset of action
  • Effective for an acute boost of mental performance


  • Long-term use is associated with cognitive impairment
  • Deplete neurotransmitters in the brain
  • Are associated with addiction

2. Nootropics


  • Act as raw materials for neurotransmitter synthesis
  • Increase cellular production of energy
  • Are not addictive
  • Not associated with cognitive impairment even on long-term use


  • Do not have a rapid onset of action like stimulants


Although nootropic supplements do not have the speedy action attributed to stimulants, they have important biological benefits that cannot be derived from stimulants. Some of the renown biological benefits of nootropic supplements, especially when used to treat fatigue, include:

  • Improved energy production within brain cells
  • Enhanced circulation of blood in the brain
  • Increased levels of stress-relieving neurotransmitters
  • Reduction in levels of cortisol – the stress hormone.

When these biological benefits are combined with the nootropic benefits for cognitive functions, the overall result is a significant reduction in fatigue symptoms. This improvement not only influences your performances at work but also enhances your quality of life.

It is far more advantageous to use the best nootropics for brain fatigue than to rely on stimulants. With nootropics, you don’t risk subjecting your brain to cognitive impairment even in long-term usage.


With so many nootropic agents in the market, you may be spoilt for choice on the best nootropics for chronic fatigue syndrome. When deciding on the best neurotropic supplement to purchase, here are two important things to consider:

1. The ingredients

Ingredients determine the mechanism of action for the nootropic agent you are purchasing. The better the ingredients, the more potent the nootropic. Some of the ingredients to look for in a nootropic supplement include:

  • Ashwagandha – a powerful natural antioxidant that is majorly used to protect the immune system but also has significant benefits in reducing anxiety.
  • L-Alpha glyceryl phosphorylcholine (Alpha GPC) – a precursor of acetylcholine which improves signal transmission within the brain and directly increases the ability to process information.
  • L-Tyrosine – important for increasing the concentration of neurotransmitters in the brain, suppressing the rise in the stress hormone, cortisol, and prevents the depletion of the neurotransmitter norepinephrine.

2. The vendor

The person or place selling the nootropic supplement should be your trusted source. To identify legitimate vendors, look up customer reviews before making a purchase. You may also buy small samples, try it out first then decide whether or not you want to be a frequent customer depending on the outcome.



The use of nootropics for fatigue is on the rise. However, much is still not known about their effectiveness. Science has also not fully explored cognition and how it can be influenced by both prescription drugs and alternative medicine. It is important to be picky with nootropics. One of the stack designed to boost overall productivity, including fighting fatigur, backed by solid research is Azoth 2.0 Total Nootropic.